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More than one-half of those who experience a single episode of depression will continue to have episodes that occur as frequently as once or even twice a.
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ويقومُ الأَميتريبتيلين على زيادة تَركيز السيروتونين والنورأدرينالين (من الموادِّ الكيميائيَّة التي تُحفِّز الخلايا العصبية)، وعرقلة عمل موادَّ كيميائيَّة أخرى في المخ إلى حدٍّ أقل، لاسيَّما الأسيتيل كولين؛ فعندما يجري إفرازُ السيروتونين والنُّورأدرينالين من الخلايا العصبيَّة في الدِّماغ تعمل على التخفيف من الحالة المزاجية.
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