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تعتبر نواتج تحطيم التيتراسايكلن مواد سامة, كما أنها تسبب متلازمة "فانكوني" (وهو خلل يصيب الأنبوب الكلوي القريب في الكلية بحيث يحدث خروج الغلوكوز, الأحماض الأمينية, حمض اليوريك , الفوسفات والبيكربونات مع البول بدلا من إعادة امتصاصها).

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